Statistical Considerations in Meta-analysis of Qtl Reports: Application to Dairy Cattle
نویسندگان
چکیده
There is a clear need to make optimal use of the ever increasing number of QTL mapping studies, especially for traits of economic importance. Meta-analysis of published information provides an extremely useful and cost effective approach. Originally developed for applications in the medical and social sciences, some papers have recently been published specifically for QTL studies in livestock species. The current paper focuses on some statistical approaches to meta-analysis of (1) QTL location and (2) QTL effect. By way of illustration, published records of QTL for milk yield of dairy cattle on BTA6 have been reviewed, and the meta-analysis clearly supports the existence of two well defined chromosomal regions.
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